Gandasegui J, et al. Ivermectin and albendazole coadministration: opportunities for strongyloidiasis control. Lancet Infect Dis. 2022 Jul 15:S1473-3099(22)00369-3.
Grau-Pujol B, et al. Single-Nucleotide Polymorphisms in the Beta-Tubulin Gene and Its Relationship with Treatment Response to Albendazole in Human Soil-Transmitted Helminths in Southern Mozambique. Am J Trop Med Hyg. 2022 Jul 18:tpmd210948.
Algorta J, Krolewiecki A, Pinto F, Gold S and J Muñoz. Combination of ivermectin and albendazole: a single dose, open label, sequence randomized, crossover clinical trial in healthy volunteers. Front. Pharmacol., 14 July 2022. https://doi.org/10.3389/fphar.2022.914886
Krolewiecki, A., Enbiale, W., Gandasegui, J., et al. An adaptive phase II/III safety and efficacy randomized controlled trial of single day or three-day fixed-dose albendazole-ivermectin co-formulation versus albendazole for the treatment of Trichuris trichiura and other STH infections. ALIVE trial protocol. Gates Open Research (2022). https://doi.or/10.12688/gatesopenres.13615.1
. Volume 106 (2022): Issue 5_Suppl (May 2022): Accelerating Innovation to Impact: Learning from Triple-drug Therapy (IDA) for Lymphatic Filariasis and from Other Innovations Publication Date: 11 May 2022 https://www.ajtmh.org/page/ida
Gandasegui, J., Grau-Pujol, B., Cambra-Pelleja, M. et al. Improving stool sample processing and pyrosequencing for quantifying benzimidazole resistance alleles in Trichuris trichiura and Necator americanus pooled eggs. Parasites Vectors 14, 490 (2021). https://doi.org/10.1186/s13071-021-04941-w [Dowloand PDF]
Gelaye W, Williams NA, Kepha S, Junior AM, Fleitas PE, et al. (2021) Performance evaluation of Baermann techniques: The quest for developing a microscopy reference standard for the diagnosis of Strongyloides stercoralis. PLOS Neglected Tropical Diseases 15(2): e0009076. https://doi.org/10.1371/journal.pntd.0009076 [Download PDF]
Grau-Pujol B, Martí-Soler H, Escola V, Demontis M, Jamine JC, et al. (2021) Towards soil-transmitted helminths transmission interruption: The impact of diagnostic tools on infection prediction in a low intensity setting in Southern Mozambique. PLOS Neglected Tropical Diseases 15(10): e0009803. https://doi.org/10.1371/journal.pntd.0009803 [Download PDF]
Cools P, van Lieshout L, Koelewijn R, Addiss D, Ajjampur SSR, et al. (2020) First international external quality assessment scheme of nucleic acid amplification tests for the detection of Schistosoma and soil-transmitted helminths, including Strongyloides: A pilot study. PLOS Neglected Tropical Diseases 14(6): e0008231. https://doi.org/10.1371/journal.pntd.0008231 [Download PDF]
Gandasegui J, Martínez-Valladares M, Grau-Pujol B, Krolewiecki AJ, Balaña-Fouce R, et al. (2020) Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials. PLOS Neglected Tropical Diseases 14(2): e0007931. https://doi.org/10.1371/journal.pntd.0007931 [Download PDF]
“Accelerating Innovation to Impact: Learning from Triple-Drug Therapy (IDA) for Lymphatic Filariasis and from Other Innovations” is a Journal supplement that was led by Bridges to Development and published in The American Journal of Tropical Medicine and Hygiene in May 2022
The supplement documentsexperiencefrom the Bridges team and others, accelerating the policy development and implementation process of a new combination therapy (IDA) for lymphatic filariasis into country programmes as well as other recent innovations in NTDs. This work provides an example to help navigate and strategize how to work with diverse partners including WHO to have new more effective and efficient treatments for NTDs brought into WHO guidelines and use in national programmes.
Bridges will lead the work focused supporting country-level decision-making on introduction of the FDC in close partnership with WHO by packaging and providing evidence for guidance to countries and partners.